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The operate of SIK1 in tumorigenesis. SIK1 is really a tumor suppressor gene, which plays a vital regulatory function in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and has an effect on cancer cell proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 might also endorse c

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